Establishing appropriate animal models of disease is of vital importance in basic medical research – for which, rats and mice have become the animals of choice. However, rats are significantly superior to mice in many research areas, which strongly benefit from the larger size, superior cognition, and more human-like physiology, morphology, and genetics of rats. In this exclusive white paper, we review the research applications of rat models in Alzheimer's disease, oncology, and more.
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Entering this century, soon after the completion of the human genome project, the mouse genome was also completed. NIH embarked on the next endeavor to coordinate the knockout of every mouse gene and then study their phenotype systematically. These efforts have contributed enormously to the understanding of gene functions as well as genetic causes of human diseases.
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Cell line-derived tumor xenograft (CDX) models play an important role in basic research of tumorigenesis and metastasis, as well as drug development and treatment. Therefore, establishing a precise animal model is vital for accurate in vivo tumor studies and in advancing oncology research.
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Alzheimer’s disease (AD) maintains the highest prevalence and morbidity among neurodegenerative diseases. As the FDA approved the first-of-its-kind treatment for Alzheimer’s disease in June 2021, Alzheimer’s drug development has come into the spotlight.
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The rapidly growing branch of biomedical research known as translational medicine is aimed at the practical problems from clinical patients. A combination of molecular, cellular, and animal models in related basic and preclinical studies can help address the problems of translational research. Therefore, a major strategy of translational medical research is to combine the basic laboratory studies with the preclinical animal experimental research and rapidly move into clinical application.
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With the growing amount of coronavirus research accomplished by researchers globally, the value of the novel coronavirus (SARS-CoV-2) across many relevant research fields has been confirmed. According to big data analytics, the degree of coronavirus infection varies among different genders and different age groups. This review focusing on the analysis of the reasons behind the age preference and gender differences in patients with COVID-19 worldwide.
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With the growing amount of coronavirus research accomplished by researchers globally, the value of the novel coronavirus (SARS-CoV-2) across many relevant research fields has been confirmed. According to big data analytics, the degree of coronavirus infection varies among different genders and different age groups.
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The coronavirus disease (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has become an ongoing global health emergency. Herein, we track the virus from its origin to current research efforts, with the aim of providing inspiration for further research and vaccine development.
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